Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954494 | 0.88 | MAP4K1 (0.43) | MAP4K1GPR119 | |
| SCHEMBL24954499 | 0.87 | GPR119 (0.37) | MAP4K1GPR119ESR2 | |
| SCHEMBL30215951 | 0.85 | MAP4K1 (0.39) | MAP4K1GPR119 | |
| SCHEMBL29216559 | 0.85 | MAP4K1 (0.39) | MAP4K1GPR119 | |
| SCHEMBL30893064 | 0.85 | MAP4K1 (0.39) | MAP4K1GPR119 | |
| SCHEMBL24954379 | 0.82 | MAP4K1 (0.43) | MAP4K1 | |
| SCHEMBL22859043 | 0.79 | MAP4K1 (0.36) | MAP4K1 | |
| SCHEMBL30215928 | 0.79 | MAP4K1 (0.46) | MAP4K1GPR119MAP3K5 | |
| SCHEMBL29216551 | 0.79 | MAP4K1 (0.46) | MAP4K1GPR119MAP3K5 | |
| SCHEMBL22858721 | 0.78 | MAP4K1 (0.51) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |