Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 12/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 12/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23823258 | 1.00 | JAK2 (0.43) | JAK2JAK1GABBR2GABBR1KDR | |
| SCHEMBL30517136 | 0.81 | LATS1 (0.40) | JAK2JAK1GABBR2GABBR1JAK3 | |
| SCHEMBL19857362 | 0.81 | LATS1 (0.40) | JAK2JAK1GABBR2GABBR1JAK3 | |
| SCHEMBL19857319 | 0.81 | LATS1 (0.40) | JAK2JAK1GABBR2GABBR1JAK3 | |
| SCHEMBL3975172 | 0.80 | GABBR2 (0.44) | JAK2JAK1GABBR2GABBR1KDR | |
| SCHEMBL4717413 | 0.80 | GABBR2 (0.42) | JAK2JAK1GABBR2GABBR1KDR | |
| SCHEMBL3971399 | 0.80 | GABBR2 (0.40) | JAK2JAK1GABBR2GABBR1KDR | |
| SCHEMBL22860432 | 0.80 | GABBR2 (0.42) | JAK2JAK1GABBR2GABBR1KDR | |
| SCHEMBL25003605 | 0.79 | RAB9A (0.39) | JAK2JAK1GABBR2GABBR1PDGFRB | |
| SCHEMBL3535605 | 0.79 | MERTK (0.48) | JAK2JAK1GABBR2GABBR1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3993802-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| CN-114340634-A | Heterocyclic compounds as kinase inhibitors | 诺维逊生物股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| WO-2021003314-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | NUVATION BIO INC. (US) | 2021-01-07 | — | — | WO | disclosed |