Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 13/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 11/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2286199 | 1.00 | CA12 (0.53) | CA12CA1CA2CA9MAPT | |
| SCHEMBL2643318 | 0.89 | CA12 (0.62) | CA12CA1CA2CA9MAPT | |
| SCHEMBL2281399 | 0.87 | TP53 (0.60) | CA12CA1CA2CA9MAPT | |
| SCHEMBL2281394 | 0.87 | TP53 (0.60) | CA12CA1CA2CA9MAPT | |
| SCHEMBL10120120 | 0.85 | MAPT (0.53) | CA1CA2MAPTMEN1KMT2A | |
| SCHEMBL5962552 | 0.81 | CA12 (0.54) | CA12CA1CA2CA9MAPT | |
| SCHEMBL18780317 | 0.81 | MAPT (0.50) | CA12CA1CA2CA9MAPT | |
| SCHEMBL19272359 | 0.81 | MAPT (0.71) | CA12CA1CA2CA9MAPT | |
| SCHEMBL2281480 | 0.81 | MAPT (0.71) | CA12CA1CA2CA9MAPT | |
| SCHEMBL2281478 | 0.81 | MAPT (0.71) | CA12CA1CA2CA9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688617-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160229794-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-08-11 | — | — | US | disclosed |
| US-9334231-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-8993736-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | ENERGY, UNITED STATES DEPARTMENT OF | 2011-08-25 | — | — | US | disclosed |
| WO-2010051343-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | PPP1R10, PPP6R1, PPP6R3 | CA12 3811/4885CA1 4262/4885CA2 3960/4885 |
| US-20160229794-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | PPP1R10, PPP6R1, PPP6R3 | CA12 3811/4885CA1 4262/4885CA2 3960/4885 |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | PPP1R10, PPP6R1, PPP6R3 | CA12 3811/4885CA1 4262/4885CA2 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.