Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 6/20 | 0.74 |
| ▸ | PTGS2 known ✓ | P35354 | 6/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.74 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.74 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.74 |
| ▸ | THPO | P40225 | 1/20 | 0.74 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.74 |
| ▸ | GLI1 | P08151 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL2287423 | 0.89 | PTGS1 (0.88) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL27834432 | 0.86 | PTGS1 (0.88) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| R-Ketoprofen SCHEMBL29353694 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| R-Ketoprofen SCHEMBL195303 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Dexketoprofen SCHEMBL66987 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Dexketoprofen SCHEMBL29396875 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL679920 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL3843886 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL8754790 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL16757741 | 0.86 | PTGS1 (1.00) | PTGS1PTGS2MAPTALDH1A1CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7988952-B2 | Condensation aerosol formed by heating a thin layer containing the ester, on a solid support to produce a vapor of the ester, and condensing; less than 10% ester degradation products by weight, and a Mass median aerodynamic diameter of less than 5 microns | ALEXZA PHARMACEUTICALS, INC. (US) | 2011-08-02 | — | — | US | disclosed |
| US-20080175796-A1 | Delivery of Drug Esters Through an Inhalation Route | ALEXZA PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | US | disclosed |
| US-7078019-B2 | Delivery of drug esters through an inhalation route | ALEXZA PHARMACEUTICALS, INC. (US) | 2006-07-18 | — | — | US | disclosed |
| US-7070765-B2 | Delivery of drug esters through an inhalation route | ALEXZA PHARMACEUTICALS, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| US-6737042-B2 | AEROSOL COMPRISES PARTICLES COMPRISING AT LEAST 10 PERCENT BY WEIGHT OF A DRUG ESTER. | ALEXZA MOLECULAR DELIVERY CORPORATION | 2004-05-18 | — | — | US | disclosed |