Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28937025 | 1.00 | MAPT (0.53) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL8574354 | 0.84 | ALDH1A1 (0.65) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL8574351 | 0.84 | ALDH1A1 (0.65) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL18763049 | 0.79 | TGM2 (0.69) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL1398153 | 0.77 | MEN1 (0.68) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL1398151 | 0.77 | MEN1 (0.68) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL9289784 | 0.77 | MEN1 (0.68) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL12835311 | 0.76 | ALDH1A1 (0.72) | MAPTMEN1KMT2ANPSR1GPR35 | |
| SCHEMBL11442860 | 0.76 | MEN1 (0.57) | MAPTMEN1KMT2ACYP1A2NPSR1 | |
| SCHEMBL7692960 | 0.75 | GPR35 (0.74) | MAPTGPR35P2RX1LMNAACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269756-B | 4-Oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds that inhibit EIF4E | 效应疗法股份有限公司 | 2024-05-14 | — | — | CN | disclosed |
| CN-114269756-A | 4-oxo-3, 4-dihydropyrido [3,4-D ] pyrimidine compounds inhibiting EIF4E | 效应疗法股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| WO-2021003157-A1 | EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS | EFFECTOR THERAPEUTICS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |