Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24933371 | 0.82 | HSD17B1 (0.44) | HSD17B1HSD17B2CYP11B1CYP11B2TBK1 | |
| SCHEMBL30359903 | 0.74 | HSD17B2 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL22867474 | 0.74 | HSD17B2 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL22867475 | 0.74 | HSD17B2 (0.80) | HSD17B1HSD17B2 | |
| SCHEMBL29582020 | 0.74 | HSD17B2 (0.80) | HSD17B1HSD17B2 | |
| SCHEMBL22867491 | 0.73 | HSD17B2 (0.82) | HSD17B1HSD17B2 | |
| SCHEMBL30359778 | 0.73 | HSD17B2 (0.82) | HSD17B1HSD17B2 | |
| SCHEMBL22868093 | 0.71 | SYK (0.44) | HSD17B1HSD17B2SYKKAT2BBAZ2B | |
| SCHEMBL24932946 | 0.71 | XDH (0.42) | HSD17B1HSD17B2SCN8A | |
| SCHEMBL24933486 | 0.70 | BRS3 (0.39) | HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3994125-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | Regeneron Pharmaceuticals, Inc. (US) | 2022-05-11 | — | — | EP | disclosed |
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |