Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.40 |
| ▸ | PDE4A | P27815 | 4/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868088 | 0.85 | SYK (0.41) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL22867965 | 0.72 | ROCK2 (0.43) | ROCK2ROCK1HSD17B1HSD17B2IRAK4 | |
| SCHEMBL22868089 | 0.71 | HSD17B1 (0.58) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL10237458 | 0.69 | TYK2 (0.41) | KAT2BBAZ2BIRAK4LRRK2 | |
| SCHEMBL12970631 | 0.68 | PARP15 (0.54) | PDE4DPDE4BPDE4APDE4CTBK1 | |
| SCHEMBL24735664 | 0.66 | PDE4D (0.54) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL30278221 | 0.66 | PDE4D (0.54) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1377003 | 0.66 | KAT2B (0.69) | SYKPDE4DPDE4BPDE4APDE4C | |
| SCHEMBL28945888 | 0.65 | PDE4D (0.53) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL18669536 | 0.64 | ROCK2 (0.55) | ROCK2ROCK1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |