Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868092 | 0.85 | KDM4E (0.50) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL14966971 | 0.83 | KDM4E (0.56) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL3415239 | 0.80 | KDM4E (0.53) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL7008118 | 0.78 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDPOLB | |
| SCHEMBL22867967 | 0.77 | KDM4E (0.43) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL29581640 | 0.77 | UCHL1 (0.43) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL31214401 | 0.76 | GAA (0.43) | KDM4EIDO1ALDH1A1MAPTNFKB1 | |
| SCHEMBL6731339 | 0.75 | KDM4E (0.64) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL2703185 | 0.75 | KDM4E (0.48) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL22867966 | 0.75 | JAK2 (0.42) | KDM4EIDO1NPSR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |