Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | JUN | P05412 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868094 | 0.85 | KDM4E (0.49) | KDM4EIDO1NPSR1ALDH1A1HPGD | |
| SCHEMBL29581640 | 0.80 | UCHL1 (0.43) | KDM4EIDO1NPSR1ALDH1A1HPGD | |
| SCHEMBL7008118 | 0.79 | KDM4E (0.53) | KDM4EALDH1A1HPGDCA12CA1 | |
| SCHEMBL22867967 | 0.78 | KDM4E (0.43) | KDM4EIDO1NPSR1ALDH1A1MAPT | |
| SCHEMBL31214401 | 0.77 | GAA (0.43) | KDM4EIDO1ALDH1A1MAPTNFKB1 | |
| SCHEMBL6731339 | 0.76 | KDM4E (0.64) | KDM4EIDO1NPSR1ALDH1A1HPGD | |
| SCHEMBL22867966 | 0.76 | JAK2 (0.42) | KDM4EIDO1NPSR1ALDH1A1HPGD | |
| SCHEMBL22868088 | 0.75 | SYK (0.41) | KDM4EIDO1NPSR1ALDH1A1HSD17B2 | |
| SCHEMBL15633138 | 0.74 | JUN (0.57) | KDM4EALDH1A1MAPTJUNNFKB1 | |
| SCHEMBL31214336 | 0.73 | POLB (0.45) | KDM4ENPSR1ALDH1A1HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |