Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 10/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19751336 | 0.78 | SIRT2 (0.45) | MAOBSIRT2ACHE | |
| SCHEMBL19732873 | 0.72 | SIGMAR1 (0.43) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL9740397 | 0.70 | HTR2C (0.32) | SIRT2 | |
| SCHEMBL19732867 | 0.70 | SIGMAR1 (0.41) | ALDH1A1KMT2AMEN1SIRT2 | |
| SCHEMBL14049600 | 0.69 | KDM4E (0.36) | KDM4EALDH1A1HTTMAOBACHE | |
| SCHEMBL22868103 | 0.68 | SIRT2 (0.52) | KDM4EKMT2AMAOBSIRT2RAB9A | |
| SCHEMBL22868097 | 0.68 | HTR2A (0.33) | — | |
| SCHEMBL10381879 | 0.67 | SIGMAR1 (0.47) | KDM4EALDH1A1HPGDMAOBACHE | |
| SCHEMBL19732888 | 0.66 | GRM2 (0.38) | MAOBSIRT2ACHE | |
| SCHEMBL22867442 | 0.66 | HSD17B2 (0.39) | KMT2AMAOBSIRT2METAP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |