Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.66 |
| ▸ | CCR3 | P51677 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.55 |
| ▸ | BACE1 | P56817 | 3/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156315 | 0.79 | ACHE (1.00) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL8315434 | 0.79 | ACHE (0.71) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL3366239 | 0.79 | ACHE (0.67) | ACHECCR3SIGMAR1DRD2DRD4 | |
| Ammonia Solution, Strong SCHEMBL2945383 | 0.78 | ACHE (0.96) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL803462 | 0.77 | CCR3 (0.67) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL4257757 | 0.77 | ACHE (0.69) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL2010139 | 0.77 | ACHE (0.69) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL7363662 | 0.77 | ACHE (0.69) | ACHECCR3SIGMAR1DRD2DRD4 | |
| SCHEMBL2735346 | 0.76 | CCR3 (0.71) | ACHECCR3SIGMAR1DRD2DRD4 | |
| Ethane SCHEMBL27302230 | 0.76 | ACHE (0.68) | ACHECCR3SIGMAR1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763712-B1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | HAIHE BIOPHARMA CO LTD (CN) | 2021-11-24 | — | — | EP | disclosed |
| EP-3763712-A1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2021-01-13 | — | — | EP | disclosed |