Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | CA4 | P22748 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL3618611 | 1.00 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL1860121 | 0.96 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL578983 | 0.96 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL52363 | 0.96 | FFAR3 (0.53) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL1118869 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL28696942 | 0.92 | FFAR3 (0.56) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL27852116 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL7567495 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL3618696 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Propionic Acid SCHEMBL28760200 | 0.92 | FFAR3 (0.50) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8261734-B2 | Heat generating body, heat insulating method using the same and packaging material for die molding heat generation | MYCOAL CO., LTD. (JP) | 2012-09-11 | — | — | US | disclosed |
| US-7998183-B2 | Heat generating body | MYCOAL CO., LTD. (JP) | 2011-08-16 | — | — | US | disclosed |
| CN-1496395-B | Heat-generating composition and heat-generating body | MAIKOORU K K | 2010-04-28 | — | — | CN | disclosed |
| US-20090007899-A1 | Wettable Heat Generating Composition Compressed Body, Heat Generating Body, and Process for Producing Wettable Heat Generating Composition Compressed Body | MYCOAL PRODUCTS CORPORATION (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090000610-A1 | Microheater and Process For Producing the Same | MYCOAL PRODUCTS CORPORATION (JP) | 2009-01-01 | — | — | US | disclosed |
| US-20080283036-A1 | Process for Producing Heat Generating Mixture, Heat Generating Mixture, Heat Generating Composition, and Heat Generating Body | MYCOAL PRODUCTS CORPORATION (JP) | 2008-11-20 | — | — | US | disclosed |
| US-20080283038-A1 | Heat Generating Body | MYCOAL PRODUCTS CORPORATION (JP) | 2008-11-20 | — | — | US | disclosed |
| US-20080269850-A1 | Flexible Heat Generating Body | MYCOAL PRODUCTS CORPORATION (JP) | 2008-10-30 | — | — | US | disclosed |
| US-20080257333-A1 | Foot Warming Heat Generating Body and Process for Producing Foot Warming Heat Generating Body | MYCOAL PRODUCTS CORPORATION (JP) | 2008-10-23 | — | — | US | disclosed |
| US-20080251062-A1 | Heat Cloth and Process for Producing the Same | MYCOAL PRODUCTS CORPORATION (JP) | 2008-10-16 | — | — | US | disclosed |
| US-20060112699-A1 | Refrigerating device, refrigerating method, and refrigerated object | GLOCAL CO., LTD (JP) | 2006-06-01 | — | — | US | disclosed |
| EP-1577363-A1 | EXOTHERMIC COMPOSITION AND EXOTHERMIC ELEMENT | Mycoal Products Corporation (JP) | 2005-09-21 | — | — | EP | disclosed |
| EP-1516900-A1 | HEATING COMPOSITION AND HEATING ELEMENT | Mycoal Warmers Co., Ltd (JP) | 2005-03-23 | — | — | EP | disclosed |
| EP-1515102-A1 | Freezer, freezing method and frozen objects | Glocal Co., Ltd. (JP) | 2005-03-16 | — | — | EP | disclosed |
| US-20040217325-A1 | Heating composition and heating element | MYCOAL WARMERS CO., LTD. (JP) | 2004-11-04 | — | — | US | disclosed |
| EP-1460120-A1 | ANION GENERATING MATERIAL AND SKIN TREATING AGENT USING THE SAME | Litec Corporation (JP) | 2004-09-22 | — | — | EP | disclosed |
| EP-1439213-A1 | EXOTHERMIC COMPOSITION AND EXOTHERMIC ARTICLE USING THE COMPOSITION, AND METHOD FOR PRODUCING THE EXOTHERMIC ARTICLE | Mycoal Warmers Co., Ltd (JP) | 2004-07-21 | — | — | EP | disclosed |
| CN-1496395-A | Heat-generating composition and heat-generating body | 麦考尔株式会社 | 2004-05-12 | — | — | CN | disclosed |
| CN-1491271-A | Heat-generating composition, heat-generating body using the same, and method for producing heat-generating body | ������������ʽ���� | 2004-04-21 | — | — | CN | disclosed |
| US-20040042965-A1 | Exothermic composition and exothermic article using the compositions, and method for producing the exothermic article | MYCOAL WARMERS CO., LTD. (JP) | 2004-03-04 | — | — | US | disclosed |