Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WIZ | O95785 | 5/20 | 0.43 |
| ▸ | IKZF2 | Q9UKS7 | 9/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20046618 | 0.91 | CRBN (0.44) | CRBN | |
| SCHEMBL20046153 | 0.81 | BRD9 (0.43) | CRBN | |
| SCHEMBL27091258 | 0.76 | CRBN (0.55) | WIZIKZF2CRBNCSNK1A1 | |
| SCHEMBL30919857 | 0.76 | CRBN (0.55) | WIZIKZF2CRBNCSNK1A1 | |
| SCHEMBL20046150 | 0.75 | CRBN (0.41) | CRBN | |
| SCHEMBL24735131 | 0.75 | IRAK4 (0.51) | CRBN | |
| SCHEMBL29841629 | 0.75 | IRAK4 (0.51) | CRBN | |
| SCHEMBL24735575 | 0.75 | IRAK4 (0.51) | CRBN | |
| SCHEMBL24734957 | 0.75 | IRAK4 (0.51) | CRBN | |
| SCHEMBL30805366 | 0.75 | CRBN (0.55) | WIZIKZF2CRBNCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236051-B2 | Compounds and methods for the targeted degradation of androgen receptor | ARVINAS OPERATIONS, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210009528-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | Arvinas, Inc. | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210009528-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | AR, ADRM1, CRBN | WIZ 4395/4885IKZF2 3834/4885CRBN 3/4885 |
| US-11236051-B2 | Compounds and methods for the targeted degradation of androgen receptor | AR, ADRM1, CRBN | WIZ 4395/4885IKZF2 3834/4885CRBN 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.