Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | PYGL | P06737 | 1/20 | 0.37 |
| ▸ | PYGM | P11217 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | IL2 | P60568 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22874400 | 0.90 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1SYKRXFP1METAP1 | |
| SCHEMBL5227380 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RXFP1METAP1TRPA1 | |
| SCHEMBL24195797 | 0.74 | ASPH (0.46) | P4HTMSYKRXFP1METAP1TRPA1 | |
| SCHEMBL30380330 | 0.74 | LMNA (0.43) | SMN1; SMN2NPC1SYKRXFP1METAP1 | |
| SCHEMBL4922310 | 0.74 | LMNA (0.43) | SMN1; SMN2NPC1SYKRXFP1METAP1 | |
| SCHEMBL1610508 | 0.73 | NLRP3 (0.53) | NPC1SYKRXFP1LCKATR | |
| SCHEMBL29768539 | 0.73 | P4HTM (0.53) | SMN1; SMN2NPC1P4HTMMETAP1ALDH1A1 | |
| SCHEMBL3716281 | 0.73 | P4HTM (0.53) | SMN1; SMN2NPC1P4HTMMETAP1ALDH1A1 | |
| SCHEMBL24427984 | 0.73 | CXCR2 (0.48) | NPC1RXFP1METAP1LCKATR | |
| SCHEMBL22874499 | 0.72 | P4HTM (0.65) | NPC1P4HTMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007313-A1 | WNT ACTIVATORS AND METHODS OF USE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2021-01-14 | — | — | WO | disclosed |