Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.42 |
| ▸ | HTR2B | P41595 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22875267 | 0.79 | GRIN2B (0.43) | LMNAGRIN2BHTR2AADRA2AADRA1A | |
| SCHEMBL583721 | 0.78 | CYP1A2 (0.58) | LMNASIGMAR1CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL8017800 | 0.76 | CYP1A2 (0.56) | LMNACYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL6064058 | 0.76 | CYP1A2 (0.61) | LMNASIGMAR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7987714 | 0.76 | IDO1 (0.39) | LMNAGRIN2BADRA1AGRIN1GRIN2D | |
| SCHEMBL22874976 | 0.76 | CYP2D6 (0.44) | LMNAGRIN2BHTR2AADRA2AADRA1A | |
| SCHEMBL22875302 | 0.74 | PSMB5 (0.41) | DRD2SLC6A4 | |
| SCHEMBL4131831 | 0.73 | SLC6A4 (0.63) | SIGMAR1SLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL10454919 | 0.73 | KCNA5 (0.49) | LMNASIGMAR1TSHRKCNH2MEN1 | |
| SCHEMBL7952371 | 0.73 | ACHE (0.66) | LMNASIGMAR1DRD2DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | C4 THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | C4 THERAPEUTICS, INC. (US) | 2021-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11753397-B2 | Cereblon binders for the degradation of ikaros | CRBN, IKZF1, IKZF3 | LMNA 1840/4885TDP1 3415/4885TRPA1 4823/4885 |
| US-20210009559-A1 | CEREBLON BINDERS FOR THE DEGRADATION OF IKAROS | CRBN, IKZF1, IKZF3 | LMNA 1482/4885TDP1 3104/4885TRPA1 4715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.