Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.42 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29700358 | 0.91 | LMNA (0.49) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL674463 | 0.91 | LMNA (0.49) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL8957048 | 0.91 | LMNA (0.49) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL18164971 | 0.85 | LMNA (0.45) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL8002029 | 0.85 | TP53 (0.49) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL12156674 | 0.85 | TSHR (0.45) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL12156754 | 0.85 | ALDH1A1 (0.46) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL18149030 | 0.84 | GLA (0.47) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL3398661 | 0.83 | LMNA (0.46) | RAB9AL3MBTL1LMNATSHRPOLB | |
| SCHEMBL8735577 | 0.83 | ALDH1A1 (0.50) | RAB9AL3MBTL1LMNATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |