SCHEMBL22878622

SCHEMBL22878622

CON(C)C(=O)c1ccc(C2CC2)c(Cl)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 4/20 0.40
SLC6A2 P23975 3/20 0.40
SLC6A4 P31645 3/20 0.40
MLYCD O95822 1/20 0.40
SIGMAR1 Q99720 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
OPRM1 P35372 1/20 0.37
OPRD1 P41143 1/20 0.37
OPRK1 P41145 1/20 0.37
OPRL1 P41146 1/20 0.36
TAS1R3 Q7RTX0 1/20 0.36
TAS1R1 Q7RTX1 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HSP90AB1 P08238 1/20 0.36
POLB P06746 1/20 0.36
HSD11B1 P28845 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21407891 0.80 MLYCD (0.39) SLC6A3SLC6A2SLC6A4MLYCDSIGMAR1
SCHEMBL21422366 0.80 MLYCD (0.39) SLC6A3SLC6A2SLC6A4MLYCDSIGMAR1
SCHEMBL2655175 0.80 SLC6A3 (0.54) SLC6A3SLC6A2SLC6A4MLYCDSIGMAR1
SCHEMBL15778276 0.79 SLC6A3 (0.53) SLC6A3SLC6A2SLC6A4CYP1A2CYP3A4
SCHEMBL8988251 0.77 MLYCD (0.45) SLC6A3SLC6A2SLC6A4MLYCDHSP90AA1
SCHEMBL31701648 0.76 SLC6A4 (0.47) SLC6A3SLC6A2SLC6A4SIGMAR1CYP1A2
SCHEMBL256724 0.76 MLYCD (0.44) SLC6A3MLYCDSIGMAR1CYP1A2CYP3A4
SCHEMBL1438344 0.76 MLYCD (0.48) SLC6A3MLYCDTSHRTAS1R3TAS1R1
SCHEMBL31073591 0.76 MLYCD (0.48) SLC6A3MLYCDTSHRTAS1R3TAS1R1
SCHEMBL3706341 0.76 MEN1 (0.58) SLC6A3MLYCDTSHRHSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3760616-A1 4-METHYLDIHYDROPYRIMIDINONE COMPOUND AND MEDICINAL USE THEREOF Japan Tobacco Inc. (JP) 2021-01-06 EP disclosed