Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21407891 | 1.00 | MLYCD (0.39) | MLYCDSLC6A3SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL21407827 | 0.82 | PDK1 (0.45) | SLC6A3CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL21422375 | 0.82 | PDK1 (0.45) | SLC6A3CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL22878622 | 0.80 | SLC6A3 (0.40) | MLYCDSLC6A3SIGMAR1CYP1A2CYP3A4 | |
| SCHEMBL24055157 | 0.80 | CHRNA1 (0.43) | MEN1KMT2ASCN9ASMN1; SMN2SLC6A4 | |
| SCHEMBL21407844 | 0.80 | CHRNA1 (0.43) | MEN1KMT2ASCN9ASMN1; SMN2SLC6A4 | |
| SCHEMBL21407909 | 0.80 | TSHR (0.47) | SLC6A3TSHRMEN1KMT2ASCN9A | |
| SCHEMBL21422372 | 0.80 | TSHR (0.47) | SLC6A3TSHRMEN1KMT2ASCN9A | |
| SCHEMBL30920055 | 0.80 | CHRNA1 (0.43) | MEN1KMT2ASCN9ASMN1; SMN2SLC6A4 | |
| SCHEMBL2655175 | 0.75 | SLC6A3 (0.54) | MLYCDSLC6A3SIGMAR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210363110-A1 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2021-11-25 | — | — | US | disclosed |
| US-20190300488-A1 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | SHIONOGI & CO., LTD. (JP) | 2019-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210363110-A1 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | RORC, RORB, RORA | MLYCD 3437/4885SLC6A3 3675/4885SIGMAR1 850/4885 |
| US-20190300488-A1 | 4-METHYLDIHYDROPYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | RORC, RORB, RORA | MLYCD 3437/4885SLC6A3 3675/4885SIGMAR1 850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.