Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | USP7 | Q93009 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229385 | 0.82 | SMN1; SMN2 (0.74) | HTTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2218247 | 0.66 | SMN1; SMN2 (1.00) | HTTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6068656 | 0.65 | LMNA (0.71) | HTTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2221128 | 0.64 | SMN1; SMN2 (0.89) | HTTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1543129 | 0.63 | LMNA (0.52) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2219477 | 0.62 | KMT2A (0.96) | HTTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2227878 | 0.62 | SMN1; SMN2 (0.70) | HTTTP53SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8288091 | 0.61 | CACNA2D1 (1.00) | CACNA2D1 | |
| SCHEMBL25226073 | 0.61 | POLB (0.51) | HTTSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL28956586 | 0.61 | ACHE (0.40) | HTTTP53SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523938-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | Hybrigenics S.A. (FR) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086178-A1 | AMIDOACRIDINE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 7 | HYBRIGENICS SA (FR) | 2011-07-21 | — | — | WO | disclosed |