Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484042 | 0.81 | LMNA (0.60) | LMNAHRH3KMT2AMEN1RAB9A | |
| SCHEMBL1543183 | 0.75 | LMNA (0.56) | LMNAALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL1018356 | 0.75 | HDAC4 (0.52) | MLYCDALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL12069267 | 0.74 | LMNA (0.56) | LMNAALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL12067875 | 0.74 | LMNA (0.61) | LMNAHRH3ALDH1A1KMT2AMEN1 | |
| SCHEMBL3629060 | 0.74 | ALDH1A1 (0.77) | LMNAALDH1A1HPGDKMT2AHDAC4 | |
| SCHEMBL6427350 | 0.73 | LMNA (0.51) | LMNAHRH3HDAC1HDAC3HDAC8 | |
| SCHEMBL14065568 | 0.73 | LMNA (0.52) | LMNAHRH3ALDH1A1KMT2AMEN1 | |
| SCHEMBL12507020 | 0.73 | LMNA (0.52) | LMNAHRH3ALDH1A1KMT2AMEN1 | |
| SCHEMBL12414328 | 0.71 | LMNA (0.51) | LMNAHRH3ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071219-B2 | Mono-acylated o-phenylendiamines derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-07-04 | — | — | US | disclosed |