Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22890045 | 0.74 | EGLN1 (0.34) | KDM4EL3MBTL1HTTMAPK1LRRK2 | |
| SCHEMBL22890488 | 0.73 | KDM4E (0.42) | KDM4EL3MBTL1HTTMAPK1CYP11B2 | |
| SCHEMBL14988176 | 0.72 | CSNK1A1 (0.40) | KDM4EL3MBTL1HTTGLAMAPK1 | |
| SCHEMBL22890442 | 0.70 | LRRK2 (0.36) | KDM4ELRRK2ALDH1A1KMT2ACSNK1A1 | |
| SCHEMBL22890264 | 0.70 | LRRK2 (0.40) | LRRK2ALDH1A1KMT2A | |
| SCHEMBL30112211 | 0.69 | LRRK2 (0.38) | LRRK2ALDH1A1 | |
| SCHEMBL25020899 | 0.68 | KDM4E (0.44) | KDM4EL3MBTL1HTTCYP11B2ALDH1A1 | |
| SCHEMBL10037033 | 0.68 | SMN1; SMN2 (0.43) | KDM4EL3MBTL1HTTGLAMAPK1 | |
| SCHEMBL14988456 | 0.68 | ALDH1A1 (0.36) | KDM4EL3MBTL1MAPK1MEN1ALDH1A1 | |
| SCHEMBL25270925 | 0.66 | NOS3 (0.35) | KDM4EL3MBTL1HTTGLACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |