Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22890769 | 0.80 | RAB9A (0.57) | TDP1MAPTKMT2AMEN1POLB | |
| SCHEMBL27981799 | 0.76 | ALDH1A1 (0.40) | TDP1MAPTKMT2ARAB9AL3MBTL1 | |
| SCHEMBL20695025 | 0.75 | ALDH1A1 (0.57) | TDP1MAPTKMT2APOLBMAOB | |
| SCHEMBL23812434 | 0.73 | ALDH1A1 (0.63) | TDP1MAPTKMT2APOLBMAOB | |
| SCHEMBL20695026 | 0.72 | ALDH1A1 (0.60) | TDP1MAPTKMT2AMEN1USP2 | |
| SCHEMBL23812446 | 0.71 | TDP1 (0.60) | TDP1MAPTKMT2AMEN1POLB | |
| SCHEMBL4771212 | 0.71 | ALDH1A1 (0.60) | TDP1MAPTKMT2APOLBRAB9A | |
| SCHEMBL30984114 | 0.71 | ALDH1A1 (0.51) | TDP1MAPTKMT2APOLBRAB9A | |
| SCHEMBL19481317 | 0.71 | ALDH1A1 (0.51) | TDP1MAPTKMT2APOLBMAOB | |
| SCHEMBL4196344 | 0.70 | TDP1 (0.59) | TDP1MAPTKMT2ARAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |