SCHEMBL2289144

SCHEMBL2289144

O=C(S)c1ccc(C(F)(F)F)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.67
CES1 P23141 2/20 0.67
SRD5A2 P31213 2/20 0.57
GSK3B P49841 2/20 0.55
PTPN1 P18031 2/20 0.55
NR4A1 P22736 1/20 0.50
NR4A2 P43354 1/20 0.50
NR4A3 Q92570 1/20 0.50
MEN1 O00255 1/20 0.48
HPGD P15428 1/20 0.48
TSHR P16473 1/20 0.48
KMT2A Q03164 1/20 0.48
EPHX2 P34913 1/20 0.48
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA3 P07451 1/20 0.48
CA4 P22748 1/20 0.48
CA6 P23280 1/20 0.48
CA5A P35218 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3172262 0.80 CES2 (1.00) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL648641 0.80 SRD5A2 (0.83) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL1178638 0.79 CA1 (0.71) CES2CES1SRD5A2HPGDTSHR
SCHEMBL349343 0.78 CES2 (0.70) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL2195841 0.78 CES2 (0.70) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL9069999 0.78 CES2 (0.70) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL1330891 0.78 SRD5A2 (0.87) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL3763045 0.78 CES2 (0.56) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL78879 0.78 SRD5A2 (0.87) CES2CES1SRD5A2GSK3BPTPN1
SCHEMBL3806036 0.78 CES2 (0.70) CES2CES1SRD5A2GSK3BPTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
CN-122071464-A Heterocyclic compound, pharmaceutical composition thereof and application thereof 上海璎黎药业有限公司 2026-05-22 CN disclosed
CN-115960047-B 3-Phenyl-1H-pyrazole compound and application thereof 中国药科大学 2025-04-15 CN disclosed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN disclosed
WO-2024067560-A1 SULFONAMIDE COMPOUND AND MEDICAL USE THEREOF 中国药科大学 2024-04-04 WO disclosed
CN-117682973-A Sulfonamide compound and medical application thereof 中国药科大学 2024-03-12 CN disclosed
EP-3568133-B1 CELL-PROTECTIVE COMPOUNDS AND THEIR USE ETH ZUERICH (CH) 2023-12-13 EP disclosed
CN-114478149-B Carboxylic acid compound and preparation method thereof 吉林化工学院 2023-09-15 CN disclosed
CN-115960047-A 3-phenyl-1H-pyrazole compound and application thereof 中国药科大学 2023-04-14 CN disclosed
CN-113968804-B Hapten and artificial antigen of monel sulfone as well as preparation methods and application of hapten and artificial antigen 中国农业大学 2022-12-02 CN disclosed
WO-2002060859-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2002-08-08 WO disclosed
US-5204482-A Ethylenediamine monoamide heteroaryl derivatives HOFFMAN-LAROCHE INC. (US) 1993-04-20 US disclosed
US-5011849-A Monoamine oxidase inhibitors HOFFMANN-LA ROCHE INC. (US) 1991-04-30 US disclosed
US-4970328-A MITICIDE, FUNGICIDE BAYER AKTIENGESELLSCHAFT (DE) 1990-11-13 US disclosed
US-4929642-A MITICIDES, FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 1990-05-29 US disclosed
EP-0002906-B1 NOVEL PERIMIDINES, THEIR PREPARATION, FORMULATIONS AND USE AS IMMUNOSUPPRESSIVES ELI LILLY AND COMPANY (US) 1982-04-14 EP disclosed
US-4294964-A IMMUNOSUPRESSIVE AGENTS ELI LILLY AND COMPANY (US) 1981-10-13 US disclosed
US-4224326-A 2-ARYL-1H-PERIMIDINES ELI LILLY AND COMPANY (US) 1980-09-23 US disclosed
EP-0002906-A2 Novel perimidines, their preparation, formulations and use as immunosuppressives ELI LILLY AND COMPANY (US) 1979-07-11 EP disclosed
US-4020169-A FROM ARYL IODIDE OR BROMIDE AND TRIFLUOROMETHYL THIO COPPER MERCK & CO., INC. (US) 1977-04-26 US disclosed