Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28708945 | 1.00 | MDM2 (0.40) | MDM2TLR2TLR1PIN1MDM4 | |
| SCHEMBL22892705 | 0.86 | KLK5 (0.46) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL29402078 | 0.85 | MDM4 (0.44) | MDM2PIN1MDM4TP53KMT2A | |
| SCHEMBL30262995 | 0.85 | MDM4 (0.44) | MDM2PIN1MDM4TP53KMT2A | |
| SCHEMBL25817017 | 0.85 | MDM4 (0.44) | MDM2PIN1MDM4TP53KMT2A | |
| SCHEMBL28700225 | 0.81 | FABP5 (0.39) | PIN1KMT2A | |
| SCHEMBL28700228 | 0.81 | FABP5 (0.39) | PIN1KMT2A | |
| SCHEMBL22892445 | 0.80 | POLB (0.45) | MDM2IDO1BACE1KMT2A | |
| SCHEMBL31000711 | 0.77 | CASP1 (0.43) | MDM2BACE1KMT2A | |
| SCHEMBL6376524 | 0.77 | CASP1 (0.43) | MDM2BACE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114080395-A | Synthesis method of alpha-amanitine and derivatives thereof | 纯生物有机有限公司 | 2022-02-22 | — | — | CN | disclosed |
| EP-3792250-A1 | SYNTHESIS OF ALPHA-AMANITIN AND ITS DERIVATIVES | Pure Bioorganics SIA (LV) | 2021-03-17 | — | — | EP | disclosed |
| WO-2021004973-A1 | SYNTHESIS OF A-AMANITIN AND ITS DERIVATIVES | PURE BIOORGANICS SIA (LV) | 2021-01-14 | — | — | WO | disclosed |