Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22894543 | 0.83 | MEN1 (0.46) | P2RX7SRD5A1MAPTKMT2ABRD4 | |
| SCHEMBL30931056 | 0.83 | MEN1 (0.46) | P2RX7SRD5A1MAPTKMT2ABRD4 | |
| SCHEMBL22894546 | 0.81 | SCN9A (0.42) | P2RX7SRD5A1KDM4EMAPTBRD4 | |
| SCHEMBL22894548 | 0.80 | SMN1; SMN2 (0.49) | P2RX7SRD5A1KDM4EMAPTKMT2A | |
| SCHEMBL29182733 | 0.80 | SLC22A12 (0.42) | P2RX7SLC22A12MAPTKMT2ACASP2 | |
| SCHEMBL27389435 | 0.79 | PTGS1 (0.42) | P2RX7KDM4EMAPTRAD52SCN9A | |
| SCHEMBL17907336 | 0.75 | CYP2D6 (0.48) | P2RX7SLC22A12KDM4EMAPTKMT2A | |
| SCHEMBL16531977 | 0.75 | P2RX7 (0.42) | P2RX7SLC22A12 | |
| SCHEMBL24719734 | 0.73 | HSD17B10 (0.46) | SLC22A12SRD5A1KDM4EKMT2ATSHR | |
| SCHEMBL16531970 | 0.73 | GLA (0.39) | P2RX7SLC22A12SRD5A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042907-B1 | DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | QUINGDAO HUANGHAI PHARMACEUTICAL CO LTD (CN) | 2021-01-13 | — | — | EP | disclosed |