Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22894543 | 0.81 | MEN1 (0.46) | TSHRLMNAHPGDCRHR1ALDH1A1 | |
| SCHEMBL30931056 | 0.81 | MEN1 (0.46) | TSHRLMNAHPGDCRHR1ALDH1A1 | |
| SCHEMBL22894546 | 0.80 | SCN9A (0.42) | TSHRHPGDL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL22894540 | 0.80 | P2RX7 (0.39) | TSHRCRHR1KDM4ESRD5A1P2RX7 | |
| SCHEMBL18065422 | 0.78 | LMNA (0.43) | SMN1; SMN2TSHRLMNAHPGDL3MBTL1 | |
| SCHEMBL14864862 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2LMNAL3MBTL1ALDH1A1POLB | |
| SCHEMBL17907343 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRLMNAHPGDL3MBTL1 | |
| SCHEMBL24196400 | 0.75 | PARP1 (0.38) | P2RX7BRD4PARP1SCN9ASCN10A | |
| SCHEMBL22894471 | 0.75 | TP53 (0.32) | SMN1; SMN2TSHRLMNAHPGDL3MBTL1 | |
| SCHEMBL17907285 | 0.74 | LMNA (0.40) | SMN1; SMN2TSHRLMNAHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042907-B1 | DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | QUINGDAO HUANGHAI PHARMACEUTICAL CO LTD (CN) | 2021-01-13 | — | — | EP | disclosed |