Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.49 |
| ▸ | IDH1 | O75874 | 2/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.48 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CCNK | O75909 | 6/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23292416 | 1.00 | CDK12 (0.49) | CDK12IDH1USP30MAPK3HDAC4 | |
| SCHEMBL28541041 | 1.00 | CDK12 (0.49) | CDK12IDH1USP30MAPK3HDAC4 | |
| SCHEMBL22895533 | 0.88 | USP30 (0.52) | CDK12IDH1USP30CCNKCDK13 | |
| SCHEMBL23292274 | 0.88 | USP30 (0.52) | CDK12IDH1USP30CCNKCDK13 | |
| SCHEMBL28552023 | 0.88 | USP30 (0.52) | CDK12IDH1USP30CCNKCDK13 | |
| SCHEMBL28544916 | 0.87 | CDK12 (0.56) | CDK12IDH1USP30CCNKCDK13 | |
| SCHEMBL23292333 | 0.87 | CDK12 (0.56) | CDK12IDH1USP30CCNKCDK13 | |
| SCHEMBL22895770 | 0.87 | CDK12 (0.56) | CDK12IDH1USP30CCNKCDK13 | |
| SCHEMBL23292227 | 0.87 | CDK12 (0.65) | CDK12IDH1USP30MAPK3HDAC4 | |
| SCHEMBL22895468 | 0.87 | CDK12 (0.65) | CDK12IDH1USP30MAPK3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358958-B2 | — | — | 2022-06-14 | — | — | US | disclosed |
| US-20210130340-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. | 2021-05-06 | — | — | US | disclosed |
| CN-112638373-A | Cyclin-dependent kinase inhibitors | 金耐特生物制药公司 | 2021-04-09 | — | — | CN | disclosed |
| US-10894788-B2 | Inhibitors of cyclin-dependent kinases | KINNATE BIOPHARMA INC. (US) | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358958-B2 | — | CDK2, CDK1, CDK6 | CDK12 19/4885IDH1 581/4885USP30 1508/4885 |
| US-20210130340-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | CDK2, CCNK, CDK1 | CDK12 22/4885IDH1 781/4885USP30 1863/4885 |
| US-10894788-B2 | Inhibitors of cyclin-dependent kinases | CDK2, CCNK, CDK1 | CDK12 22/4885IDH1 781/4885USP30 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.