Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | AADAT | Q8N5Z0 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20027984 | 1.00 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL1199326 | 0.91 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL11985482 | 0.91 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL11985494 | 0.87 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL6967758 | 0.87 | RAB9A (0.51) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL27479846 | 0.78 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL9033462 | 0.77 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL9033466 | 0.77 | RAB9A (0.49) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL5674913 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL5674922 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | NPC1 2197/4885RAB9A 2461/4885SMN1; SMN2 200/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | NPC1 1945/4885RAB9A 2055/4885SMN1; SMN2 263/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | NPC1 2197/4885RAB9A 2461/4885SMN1; SMN2 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.