SCHEMBL22897465

SCHEMBL22897465

COc1ccc(-n2cnc(Br)n2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
ADORA3 P0DMS8 1/20 0.44
HTT P42858 2/20 0.43
RAB9A P51151 3/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
NPC1 O15118 2/20 0.42
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
P2RX7 Q99572 1/20 0.41
MAPT P10636 5/20 0.40
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22897771 0.85 CYP1A2 (0.38) CYP1A2CYP2C9ADORA3RAB9AKMT2A
SCHEMBL22897834 0.83 MAPT (0.47) CYP1A2CYP2C9RAB9AKMT2AMEN1
SCHEMBL17454042 0.81 KMT2A (0.40) KMT2AMAPTTP53POLBALDH1A1
SCHEMBL6615348 0.80 CYP1A2 (0.48) CYP1A2CYP2C9ADORA3HTTRAB9A
SCHEMBL16202001 0.80 CYP1A2 (0.48) CYP1A2CYP2C9ADORA3HTTRAB9A
SCHEMBL16073029 0.79 ALDH1A1 (0.43) ADORA3HTTRAB9AKMT2AMEN1
SCHEMBL6132524 0.79 CYP1A2 (0.47) CYP1A2CYP2C9ADORA3HTTRAB9A
SCHEMBL14577291 0.78 RXRA (0.42) CYP1A2MAPTL3MBTL1PTGS2SMN1; SMN2
SCHEMBL6614645 0.76 CYP1A2 (0.44) CYP1A2CYP2C9ADORA3HTTRAB9A
SCHEMBL22660837 0.76 PTGS1 (0.39) CYP1A2CYP2C9RAB9ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114072000-A Molecules having certain pesticidal effects and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2022-02-18 CN disclosed
WO-2021011722-A1 MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2021-01-21 WO disclosed