SCHEMBL22897782

SCHEMBL22897782

Nc1ccc(-c2cn(-c3ccc(OC(F)(F)F)cc3)nn2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 4/20 0.56
CA2 P00918 4/20 0.56
CA12 O43570 1/20 0.56
CA9 Q16790 1/20 0.56
S1PR1 P21453 1/20 0.54
S1PR3 Q99500 1/20 0.54
PTGS2 P35354 5/20 0.49
CA5A P35218 3/20 0.49
CA5B Q9Y2D0 3/20 0.49
RXRA P19793 5/20 0.48
GRIN1 Q05586 5/20 0.48
GRIN2B Q13224 5/20 0.48
FLT1 P17948 1/20 0.47
KDR P35968 1/20 0.47
P2RY14 Q15391 2/20 0.47
PTGS1 P23219 1/20 0.47
STS P08842 2/20 0.45
MAPT P10636 2/20 0.44
MAPK1 P28482 2/20 0.44
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23557702 0.86 CA1 (0.56) CA1CA2CA12CA9S1PR1
SCHEMBL18031102 0.86 CA1 (0.56) CA1CA2CA12CA9S1PR1
SCHEMBL23557745 0.84 STS (0.67) CA1CA2CA12CA9S1PR1
SCHEMBL22897927 0.81 CA1 (0.54) CA1CA2CA12CA9S1PR1
SCHEMBL20393724 0.80 RXRA (0.54) CA1CA2CA12CA9S1PR1
SCHEMBL31530390 0.79 STS (0.58) CA1CA2CA12CA9PTGS2
SCHEMBL1259204 0.78 SCN5A (0.50) MAPTMAPK1KDM4EGAARECQL
SCHEMBL18031615 0.77 HSD17B1 (0.70) CA1CA2CA12CA9S1PR1
SCHEMBL28949786 0.77 HSD17B1 (0.61) CA1CA2CA12CA9PTGS2
SCHEMBL11904306 0.76 CA1 (0.57) CA1CA2CA12CA9PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114072000-A Molecules having certain pesticidal effects and intermediates, compositions and methods related thereto 科迪华农业科技有限责任公司 2022-02-18 CN disclosed
WO-2021011722-A1 MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2021-01-21 WO disclosed