Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPER1 | Q99527 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 3/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 3/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900276 | 0.76 | NMT1 (0.41) | — | |
| SCHEMBL22900415 | 0.76 | QPCT (0.37) | GPER1 | |
| SCHEMBL22900623 | 0.76 | QPCT (0.37) | GPER1 | |
| SCHEMBL22900331 | 0.74 | BRD4 (0.37) | GPER1 | |
| SCHEMBL22900277 | 0.74 | BRD4 (0.37) | GPER1 | |
| SCHEMBL30402974 | 0.66 | GPER1 (0.39) | GPER1PDE3BPDE3ASYKFFAR2 | |
| SCHEMBL24196345 | 0.65 | FFAR2 (0.40) | GPER1PDE3BPDE3AFFAR2PIK3CA | |
| SCHEMBL29049683 | 0.65 | DRD3 (0.44) | GPER1PDE3BPDE3ASYKFFAR2 | |
| SCHEMBL24196343 | 0.65 | FFAR2 (0.40) | GPER1PDE3BPDE3AFFAR2PIK3CA | |
| SCHEMBL30403514 | 0.65 | PDE3B (0.40) | GPER1PDE3BPDE3ASYKFFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |