Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402437 | 0.83 | ALDH1A1 (0.65) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL29660827 | 0.80 | ALDH1A1 (0.43) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL288785 | 0.80 | ALDH1A1 (0.59) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL622325 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL1919483 | 0.78 | ALDH1A1 (0.68) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL29660769 | 0.78 | ALDH1A1 (0.44) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL23214292 | 0.77 | LMNA (0.49) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL1921091 | 0.77 | ALDH1A1 (0.49) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL23708646 | 0.77 | ALDH1A1 (0.49) | ALDH1A1CYP1A2HPGDLMNAMAPT | |
| SCHEMBL2885576 | 0.75 | ALDH1A1 (0.47) | ALDH1A1CYP1A2HPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |