SCHEMBL22901677

SCHEMBL22901677

CC(C)(C)n1cnc2c(N)cccc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 2/20 0.45
PI4K2B Q8TCG2 2/20 0.45
PI4K2A Q9BTU6 2/20 0.45
PI4KB Q9UBF8 2/20 0.45
DDB1 Q16531 1/20 0.42
CRBN Q96SW2 1/20 0.42
ADA P00813 1/20 0.40
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
TLR8 Q9NR97 1/20 0.36
PARP1 P09874 2/20 0.34
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
HPGD P15428 1/20 0.33
KDM4E B2RXH2 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MAPT P10636 4/20 0.33
TDP1 Q9NUW8 3/20 0.33
GAA P10253 2/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2062338 0.82 DDB1 (0.42) PI4KAPI4K2BPI4K2API4KBDDB1
SCHEMBL4569748 0.82 PI4KA (0.38) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL4072933 0.80 PI4KA (0.39) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL29538937 0.79 PI4KA (0.38) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL4572243 0.76 HCAR1 (0.38) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL358722 0.76 DPP4 (0.44) DDB1CRBNADAALDH1A1TLR8
SCHEMBL21636974 0.75 PI4KA (0.53) PI4KAPI4K2BPI4K2API4KBADA
Hydrochloric Acid SCHEMBL6118670 0.74 DPP4 (0.43) DDB1CRBNADAALDH1A1TLR8
Hydrochloric Acid SCHEMBL15093741 0.74 DPP4 (0.43) DDB1CRBNADAALDH1A1TLR8
SCHEMBL22399895 0.73 DDB1 (0.42) DDB1CRBNADAALDH1A1TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11795192-B2 Antimicrobial compounds, compositions, and uses thereof Lakewood Amedex, Inc. (US) 2023-10-24 US disclosed
US-11795192-B2 Antimicrobial compounds, compositions, and uses thereof Lakewood Amedex, Inc. (US) 2023-10-24 US disclosed
US-20230287034-A1 CYCLIC DINUCLEOTIDES AS STING AGONISTS JANSSEN BIOTECH INC (US) 2023-09-14 US disclosed
US-11213592-B2 Antibody-sting agonist conjugates and their use in immunotherapy IMMUNESENSOR THERAPEUTICS, INC. (US) 2022-01-04 US disclosed
US-20210290774-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-09-23 US disclosed
US-11033635-B2 Antibody-STING agonist conjugates and their use in immunotherapy IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-06-15 US disclosed
US-20210170043-A1 DC-SIGN ANTIBODY CONJUGATES COMPRISING STING AGONISTS CHINOOK THERAPEUTICS, INC. 2021-06-10 US disclosed
US-20210015941-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-01-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11213592-B2 Antibody-sting agonist conjugates and their use in immunotherapy STING1, CGAS, MAVS PI4KA 1784/4885PI4K2B 2458/4885PI4K2A 2479/4885
US-20210290774-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY STING1, CGAS, MAVS PI4KA 1784/4885PI4K2B 2458/4885PI4K2A 2479/4885
US-20230287034-A1 CYCLIC DINUCLEOTIDES AS STING AGONISTS STING1, CGAS, IFNAR1 PI4KA 2386/4885PI4K2B 2341/4885PI4K2A 2482/4885
US-11033635-B2 Antibody-STING agonist conjugates and their use in immunotherapy STING1, CGAS, MAVS PI4KA 1784/4885PI4K2B 2458/4885PI4K2A 2479/4885
US-20210170043-A1 DC-SIGN ANTIBODY CONJUGATES COMPRISING STING AGONISTS STING1, TLR9, TLR3 PI4KA 3182/4885PI4K2B 3890/4885PI4K2A 3683/4885
US-11795192-B2 Antimicrobial compounds, compositions, and uses thereof CAT, MPO, NISCH PI4KA 1930/4885PI4K2B 2372/4885PI4K2A 2532/4885
US-20210015941-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY STING1, CGAS, MAVS PI4KA 1784/4885PI4K2B 2458/4885PI4K2A 2479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.