Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 6/20 | 0.59 |
| ▸ | MAOB | P27338 | 6/20 | 0.59 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 2/20 | 0.46 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KYAT1 | Q16773 | 1/20 | 0.40 |
| ▸ | KYAT3 | Q6YP21 | 1/20 | 0.40 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7591080 | 0.78 | MAOA (0.54) | MAOAMAOBGSTP1MAPTTDP1 | |
| SCHEMBL620053 | 0.78 | ALDH1A1 (0.44) | MAOAMAOBGRM5TGM2MAPT | |
| SCHEMBL6014812 | 0.78 | CLK4 (0.48) | MAOAMAOBGRM5TGM2TDP1 | |
| SCHEMBL22169857 | 0.77 | AKR1C3 (0.55) | MAOAMAOBGRM5 | |
| SCHEMBL5894020 | 0.74 | MAOA (1.00) | MAOAMAOBTGM2GSTP1MAPT | |
| SCHEMBL618389 | 0.74 | ALDH1A1 (0.47) | MAPTTDP1L3MBTL1 | |
| SCHEMBL1745079 | 0.72 | GRM5 (0.53) | MAOAMAOBGRM5GSTP1MAPT | |
| SCHEMBL8896838 | 0.72 | MAOB (0.50) | MAOAMAOBGSTP1MAPTCA9 | |
| SCHEMBL8896688 | 0.72 | MAOB (0.65) | MAOAMAOBGSTP1MAPTTDP1 | |
| SCHEMBL22169855 | 0.72 | L3MBTL1 (0.45) | L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |