Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728316 | 0.72 | ALDH1A1 (0.45) | KDM4EALDH1A1HSD17B10MAPTTDP2 | |
| SCHEMBL11534081 | 0.71 | ALDH1A1 (0.39) | KDM4EALDH1A1HSD17B10HPGDMAOA | |
| SCHEMBL11536434 | 0.68 | MAOA (0.47) | KDM4EALDH1A1HSD17B10HPGDMAOA | |
| SCHEMBL10606625 | 0.68 | AKR1B1 (0.57) | — | |
| SCHEMBL13469502 | 0.66 | ALDH1A1 (0.52) | KDM4EALDH1A1HSD17B10HPGDCYP3A4 | |
| SCHEMBL16163017 | 0.66 | PDE7A (0.54) | KDM4EALDH1A1HSD17B10HPGDMAOA | |
| SCHEMBL29244276 | 0.63 | MAOA (0.38) | KDM4EALDH1A1HSD17B10HPGDMAPT | |
| SCHEMBL29604423 | 0.63 | MAOA (0.41) | KDM4EALDH1A1HSD17B10HPGDMAOA | |
| SCHEMBL1789178 | 0.63 | MAOA (0.41) | KDM4EALDH1A1HSD17B10HPGDMAOA | |
| SCHEMBL16163323 | 0.63 | ITGA4 (0.53) | KDM4EALDH1A1HSD17B10MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |