Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.40 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CASP9 | P55211 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904139 | 0.71 | KDR (0.34) | KDR | |
| SCHEMBL22904120 | 0.70 | MAPT (0.47) | MAPTDDB1CRBNGRIA1CACNG8 | |
| SCHEMBL22904142 | 0.69 | MEN1 (0.46) | MAPTGSK3BDDB1CRBNCASP3 | |
| SCHEMBL12783240 | 0.68 | KMT2A (0.45) | MAPTGSK3BDDB1CRBNGRIA1 | |
| SCHEMBL11942169 | 0.67 | MAPK14 (0.38) | MAPTHDAC9KMT2AMEN1MAPK14 | |
| SCHEMBL18850703 | 0.65 | HDAC9 (0.46) | HDAC9KMT2AMAPK14ALDH1A1 | |
| SCHEMBL22904122 | 0.65 | MAPT (0.47) | MAPTGSK3BDDB1CRBNGRIA1 | |
| SCHEMBL6238897 | 0.64 | MAPT (1.00) | MAPTDDB1CRBNCASP3CASP6 | |
| SCHEMBL13990279 | 0.64 | KMT2A (0.48) | MAPTGSK3BKMT2AMEN1MAPK14 | |
| SCHEMBL20886849 | 0.63 | TDP2 (0.64) | MAPTGRIA1CACNG8CASP3CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |