Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338762 | 0.71 | AADAT (0.47) | MAPTIDO1RECQLHSD17B10TSHR | |
| SCHEMBL9038732 | 0.69 | ALDH1A1 (0.53) | MEN1KMT2AMAPTIDO1RECQL | |
| SCHEMBL22904149 | 0.69 | MAPT (0.47) | MEN1KMT2AMAPTTDP2CASP3 | |
| SCHEMBL12783192 | 0.68 | POLB (0.47) | MEN1KMT2AMAPTIDO1DDB1 | |
| SCHEMBL4828802 | 0.67 | RECQL (0.41) | MAPTRECQLHSD17B10TSHRALDH1A1 | |
| SCHEMBL77739 | 0.66 | KMT2A (0.73) | MEN1KMT2AMAPTRECQLHSD17B10 | |
| SCHEMBL30020048 | 0.65 | HSD17B10 (0.54) | MAPTIDO1RECQLHSD17B10TSHR | |
| SCHEMBL4828671 | 0.65 | PSD (0.43) | MEN1KMT2AMAPTIDO1RECQL | |
| SCHEMBL29250802 | 0.63 | RECQL (0.50) | MEN1KMT2AMAPTRECQLHSD17B10 | |
| SCHEMBL21359663 | 0.63 | KMT2A (1.00) | MEN1KMT2AMAPTRECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |