Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 6/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | CASP9 | P55211 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.30 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904457 | 0.96 | TDP2 (0.36) | TDP2HAO1ALOX5GRIN1CHRNB4 | |
| SCHEMBL22904454 | 0.96 | TDP2 (0.36) | TDP2HAO1ALOX5GRIN1CHRNB4 | |
| SCHEMBL22904553 | 0.90 | TDP2 (0.39) | TDP2GRIN1CASP3CASP7CASP9 | |
| SCHEMBL22904496 | 0.90 | TDP2 (0.40) | TDP2HAO1ALOX5EIF2AK2GRM5 | |
| SCHEMBL22904102 | 0.81 | DDB1 (0.43) | HAO1 | |
| SCHEMBL22904412 | 0.80 | DDB1 (0.42) | — | |
| SCHEMBL22904461 | 0.78 | TDP2 (0.40) | TDP2EIF2AK2 | |
| SCHEMBL22904366 | 0.77 | TDP2 (0.45) | TDP2EIF2AK2CASP3CASP7CASP9 | |
| SCHEMBL22904525 | 0.74 | TDP2 (0.54) | TDP2EIF2AK2CASP3CASP7CASP9 | |
| SCHEMBL22904127 | 0.73 | TDP2 (0.48) | TDP2EIF2AK2CASP3CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |