Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | CASP9 | P55211 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904452 | 0.90 | TDP2 (0.38) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904454 | 0.86 | TDP2 (0.36) | TDP2GRIN1 | |
| SCHEMBL22904457 | 0.86 | TDP2 (0.36) | TDP2GRIN1 | |
| SCHEMBL22904250 | 0.81 | STK10 (0.33) | CASP3CASP7CASP6CASP8PPARG | |
| SCHEMBL22904153 | 0.80 | TDP2 (0.41) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904458 | 0.80 | TDP2 (0.41) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904154 | 0.80 | TDP2 (0.41) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904496 | 0.79 | TDP2 (0.40) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904525 | 0.75 | TDP2 (0.54) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904298 | 0.75 | TDP2 (0.50) | TDP2CASP3CASP7CASP9CASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |