Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904154 | 0.89 | TDP2 (0.41) | TDP2EIF2AK2 | |
| SCHEMBL22904458 | 0.89 | TDP2 (0.41) | TDP2EIF2AK2 | |
| SCHEMBL22904153 | 0.89 | TDP2 (0.41) | TDP2EIF2AK2 | |
| SCHEMBL22904366 | 0.87 | TDP2 (0.45) | TDP2EIF2AK2 | |
| SCHEMBL22904141 | 0.81 | TDP2 (0.42) | TDP2TAAR1 | |
| SCHEMBL22904454 | 0.81 | TDP2 (0.36) | TDP2EIF2AK2 | |
| SCHEMBL22904457 | 0.81 | TDP2 (0.36) | TDP2EIF2AK2 | |
| SCHEMBL22904452 | 0.78 | TDP2 (0.38) | TDP2EIF2AK2 | |
| SCHEMBL22904525 | 0.76 | TDP2 (0.54) | TDP2EIF2AK2 | |
| SCHEMBL22904127 | 0.76 | TDP2 (0.48) | TDP2EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |