Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22904154 | 1.00 | TDP2 (0.41) | TDP2MAOBMAOACASP3CASP7 | |
| SCHEMBL22904153 | 1.00 | TDP2 (0.41) | TDP2MAOBMAOACASP3CASP7 | |
| SCHEMBL22904461 | 0.89 | TDP2 (0.40) | TDP2EIF2AK2 | |
| SCHEMBL22904141 | 0.83 | TDP2 (0.42) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904553 | 0.80 | TDP2 (0.39) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904407 | 0.79 | DRD2 (0.42) | — | |
| SCHEMBL22904525 | 0.78 | TDP2 (0.54) | TDP2MAOBMAOACASP3CASP7 | |
| SCHEMBL22904274 | 0.77 | TDP2 (0.50) | TDP2MAOBMAOACASP3CASP7 | |
| SCHEMBL22904298 | 0.77 | TDP2 (0.50) | TDP2CASP3CASP7CASP9CASP6 | |
| SCHEMBL22904366 | 0.77 | TDP2 (0.45) | TDP2MAOBCASP3CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |