Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24894969 | 0.86 | TDP2 (0.51) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL22745965 | 0.80 | TDP2 (0.49) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL24895273 | 0.80 | TDP2 (0.49) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL22745997 | 0.79 | TDP2 (0.47) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL15579296 | 0.79 | CMA1 (0.49) | TDP2TGM2CES1CMA1AHR | |
| SCHEMBL31079938 | 0.79 | CMA1 (0.49) | TDP2TGM2CES1CMA1AHR | |
| SCHEMBL22745703 | 0.77 | TDP2 (0.45) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL30644266 | 0.77 | TDP2 (0.45) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL22904372 | 0.77 | TDP2 (0.45) | TDP2PARP10PARP1TGM2CES1 | |
| SCHEMBL4296570 | 0.75 | PGR (0.53) | CMA1AHRAKR1B1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011631-A1 | FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |