Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.51 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24895273 | 0.93 | TDP2 (0.49) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL22745965 | 0.93 | TDP2 (0.49) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL22745997 | 0.92 | TDP2 (0.47) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL22904499 | 0.86 | TDP2 (0.47) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL24895037 | 0.85 | TDP2 (0.47) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL24895277 | 0.84 | TDP2 (0.46) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL4296570 | 0.79 | PGR (0.53) | AKR1B1CMA1AHRKDM4EALDH1A1 | |
| SCHEMBL22745698 | 0.77 | TDP2 (0.49) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL30932956 | 0.77 | TDP2 (0.49) | TDP2AKR1A1AKR1B1PARP10PARP11 | |
| SCHEMBL204595 | 0.77 | PDK2 (0.43) | TDP2AKR1A1AKR1B1PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2023288039-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. (US) | 2023-01-19 | — | — | WO | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |