Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22907052 | 0.89 | GBA1 (0.41) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL5209182 | 0.84 | CHRM5 (0.38) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL13884111 | 0.81 | GBA1 (0.32) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22907051 | 0.81 | GBA1 (0.47) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22907460 | 0.80 | GBA1 (0.41) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22907137 | 0.79 | CHRM5 (0.46) | GBA1 | |
| SCHEMBL23204878 | 0.78 | CHRM5 (0.39) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL13884112 | 0.77 | GNAO1 (0.35) | GBA1 | |
| SCHEMBL23205510 | 0.75 | ACHE (0.35) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL23205744 | 0.75 | ACHE (0.35) | GBA1CACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |