Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.30 |
| ▸ | ARG2 | P78540 | 1/20 | 0.30 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.30 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22907051 | 0.87 | GBA1 (0.47) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL4031644 | 0.83 | GBA1 (0.42) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22907459 | 0.80 | GBA1 (0.36) | GBA1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL5648979 | 0.80 | GBA1 (0.50) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL16303417 | 0.76 | GBA1 (0.50) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL22907052 | 0.76 | GBA1 (0.41) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24717543 | 0.75 | GBA1 (0.43) | GBA1CACNA2D1CACNA1BCACNB1ACHE | |
| SCHEMBL19063632 | 0.73 | SLC6A1 (0.41) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL19063634 | 0.73 | SLC6A1 (0.41) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL19063705 | 0.73 | SLC6A1 (0.41) | GBA1GNAO1CACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |