SCHEMBL22908440

SCHEMBL22908440

CC#Cc1cc(Cl)c(C2C(=O)CC3(CCN(C(=O)c4cc(OC)ccn4)CC3)CC2=O)c(OC)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 3/20 0.37
ADRA1A P35348 2/20 0.37
CCR8 P51685 2/20 0.36
KCNH2 Q12809 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
RIPK1 Q13546 1/20 0.36
BTK Q06187 1/20 0.35
CYP3A4 P08684 3/20 0.35
NOS1 P29475 2/20 0.35
NOS2 P35228 2/20 0.35
NOS3 P29474 1/20 0.35
TRPC6 Q9Y210 1/20 0.34
CYP2D6 P10635 2/20 0.34
USP2 O75604 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
GHSR Q92847 1/20 0.33
CSF1R P07333 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22908539 0.89 CCR8 (0.47) ADRA1ACCR8KCNH2CYP1A2CYP2C9
SCHEMBL22908441 0.89 DRD3 (0.41) HTR1AADRA1ACCR8KCNH2CYP1A2
SCHEMBL21344681 0.88 CYP1A2 (0.38) HTR1AADRA1ACCR8KCNH2CYP1A2
SCHEMBL22908432 0.86 ACACA (0.33) CCR8KCNH2BTKNPC1RAB9A
SCHEMBL22908431 0.86 GRM3 (0.46) HTR1ACYP1A2CYP2C9CYP3A4CYP2D6
SCHEMBL22908552 0.86 CYP3A4 (0.44) CCR8KCNH2CYP1A2CYP2C9CYP2C19
SCHEMBL22908555 0.85 CCR8 (0.36) HTR1AADRA1ACCR8KCNH2CYP3A4
SCHEMBL22908437 0.85 MGLL (0.44) HTR1ACCR8KCNH2DRD2
SCHEMBL22908445 0.85 CYP3A4 (0.34) HTR1AADRA1ACCR8KCNH2CYP1A2
SCHEMBL22908444 0.85 EPHX2 (0.36) CCR8KCNH2CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021009048-A1 HERBICIDAL CYCLOHEXANEDIONE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed