Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22151008 | 0.87 | RAB9A (0.53) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL22908698 | 0.83 | ALDH1A1 (0.53) | ALDH1A1HPGDLMNAALOX15HSD17B10 | |
| SCHEMBL13963591 | 0.76 | MAPT (0.44) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL7156184 | 0.75 | MAPT (0.64) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL13170017 | 0.75 | RAB9A (0.54) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30511949 | 0.74 | RAB9A (0.50) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5467365 | 0.74 | RAB9A (0.50) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL15348827 | 0.73 | MEN1 (0.55) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT | |
| SCHEMBL10867778 | 0.72 | LMNA (0.67) | ALDH1A1HPGDLMNAALOX15HSD17B10 | |
| SCHEMBL2634411 | 0.72 | RAB9A (0.63) | ALDH1A1LMNARAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339161-B2 | Triazolo pyridines as modulators of gamma-secretase | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-24 | — | — | US | disclosed |
| EP-3672971-B1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BOEHRINGER INGELHEIM INT (DE) | 2021-07-14 | — | — | EP | disclosed |
| US-20210017173-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017173-A1 | TRIAZOLO PYRIDINES AS MODULATORS OF GAMMA-SECRETASE | BACE1, BACE2, APP | ALDH1A1 2894/4885HPGD 1127/4885LMNA 2702/4885 |
| US-11339161-B2 | Triazolo pyridines as modulators of gamma-secretase | BACE1, BACE2, APP | ALDH1A1 2894/4885HPGD 1127/4885LMNA 2702/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.