Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.57 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.49 |
| ▸ | PDE4A | P27815 | 3/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22908646 | 0.86 | KMT2A (0.61) | KMT2AMEN1LMNAMAPTCD274 | |
| SCHEMBL22908674 | 0.84 | KMT2A (0.70) | KMT2AMEN1LMNAMAPTCD274 | |
| SCHEMBL22908672 | 0.81 | PDCD1 (0.58) | KMT2AMEN1LMNAMAPTCD274 | |
| SCHEMBL10435326 | 0.79 | MAPT (0.75) | KMT2AMEN1LMNAMAPTCD274 | |
| SCHEMBL15057911 | 0.77 | PDCD1 (0.60) | CD274PDCD1PDE4BPDE4APDE4C | |
| SCHEMBL15058050 | 0.77 | PDE4B (0.79) | KMT2AMEN1MAPTCD274PDCD1 | |
| SCHEMBL22908677 | 0.76 | KMT2A (0.58) | KMT2AMEN1LMNAMAPTCD274 | |
| SCHEMBL22908712 | 0.75 | KMT2A (0.60) | KMT2AMEN1LMNAMAPTCD274 | |
| SCHEMBL22909488 | 0.73 | CD274 (1.00) | CD274PDCD1PDE4BPDE4APDE4C | |
| SCHEMBL10435333 | 0.73 | MAPT (0.67) | KMT2AMEN1LMNAMAPTCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009384-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE (FR) | 2021-01-21 | — | — | WO | disclosed |
| EP-3766544-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | Centre Hospitalier Regional Universitaire de Lille (FR) | 2021-01-20 | — | — | EP | disclosed |