Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | CASP6 | P55212 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22909301 | 0.85 | KMT2A (0.62) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22909304 | 0.82 | KMT2A (0.59) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22908683 | 0.81 | KMT2A (0.58) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL10435326 | 0.79 | MAPT (0.75) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22908646 | 0.79 | KMT2A (0.61) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22908674 | 0.76 | KMT2A (0.70) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL22908805 | 0.75 | MAOA (0.44) | KMT2AMAPTMEN1LMNAHPGD | |
| SCHEMBL22908675 | 0.73 | CD274 (1.00) | PDCD1CD274GAACASP6CASP3 | |
| SCHEMBL10381322 | 0.73 | PDCD1 (0.50) | PDCD1CD274KMT2AMAPTMEN1 | |
| SCHEMBL10435333 | 0.73 | MAPT (0.67) | PDCD1CD274KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009384-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE (FR) | 2021-01-21 | — | — | WO | disclosed |
| EP-3766544-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | Centre Hospitalier Regional Universitaire de Lille (FR) | 2021-01-20 | — | — | EP | disclosed |