Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261052 | 0.81 | NPC1 (0.61) | P2RX7HIF1AMAPTKDM4EMEN1 | |
| SCHEMBL21570087 | 0.78 | P2RX7 (0.53) | P2RX7HIF1ATP53NPC1RAB9A | |
| SCHEMBL11250774 | 0.76 | NPC1 (0.64) | P2RX7HIF1AMAPTKDM4EALDH1A1 | |
| SCHEMBL11258591 | 0.76 | HIF1A (0.76) | P2RX7HIF1AMAPTMEN1POLB | |
| SCHEMBL16383260 | 0.75 | MAPT (0.44) | P2RX7HIF1AMAPTKDM4EMEN1 | |
| SCHEMBL18646131 | 0.75 | POLB (0.46) | MAPTKDM4EALDH1A1POLBGAA | |
| SCHEMBL15952357 | 0.74 | LIPG (0.60) | P2RX7HIF1AMAPTKDM4EMEN1 | |
| SCHEMBL4650799 | 0.73 | HIF1A (0.59) | P2RX7HIF1APOLBIL1BTP53 | |
| SCHEMBL1180411 | 0.73 | HIF1A (0.67) | P2RX7HIF1AMAPTHPGDTP53 | |
| SCHEMBL5111555 | 0.73 | P2RX7 (0.66) | P2RX7HIF1AMEN1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484481-B1 | METHODS FOR USE IN THE TREATMENT OF CLOSTRIDIUM DIFFICILE | SCRIPPS RESEARCH INST (US) | 2021-01-20 | — | — | EP | disclosed |